|Application ||WB, IHC-P, FC, E|
|Other Accession||Q7ZXP1, Q3B8Q0, Q8R001, Q15555, Q5ZKK1, Q3SZP2, Q66HR2, Q61166, Q5ZLC7, Q3ZBD9, NP_036457.1|
|Predicted||Bovine, Chicken, Rat, Xenopus|
|Calculated MW||29999 Da|
|Antigen Region||44-71 aa|
|Other Names||Microtubule-associated protein RP/EB family member 1, APC-binding protein EB1, End-binding protein 1, EB1, MAPRE1|
|Target/Specificity||This MAPRE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-71 amino acids from the N-terminal region of human MAPRE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAPRE1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.
Jaulin, F., et al. J. Cell Biol. 190(3):443-460(2010)
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
De Groot, C.O., et al. J. Biol. Chem. 285(8):5802-5814(2010)
Jiang, K., et al. EMBO Rep. 10(8):857-865(2009)
Honnappa, S., et al. Cell 138(2):366-376(2009)
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