|Application ||WB, IHC-P, IF, FC, E|
|Other Accession||P21451, Q9N0W7, P35463, P48302, P28088, O62709|
|Predicted||Bovine, Horse, Pig, Rabbit, Rat|
|Calculated MW||49644 Da|
|Antigen Region||409-439 aa|
|Other Names||Endothelin B receptor, ET-B, ET-BR, Endothelin receptor non-selective type, EDNRB, ETRB|
|Target/Specificity||This EDNRB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 409-439 amino acids from the C-terminal region of human EDNRB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EDNRB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells|
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Provided below are standard protocols that you may find useful for product applications.
EDNRB is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene.
MacClellan,L.R., et.al., Stroke 40 (10), E550-E557 (2009)
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