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GZMM Antibody (Center)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP6792c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
GZMM Antibody (Center) - Product info | |
| Application | WB, IHC, FC
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| Primary Accession | P51124 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 27545 Da |
GZMM Antibody (Center) - Additional info | |
| Gene ID 3004 | |
| Other Names GZMM; MET1; Granzyme M; Met-1 serine protease; Met-ase; Natural killer cell granular protease | |
| Target/Specificity This GZMM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91~121 amino acids from the Center region of human GZMM. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions GZMM Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
GZMM Antibody (Center) - Protein Information | |
| Name GZMM | |
| Synonyms MET1 | |
| Function Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells | |
| Cellular Location Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes | |
| Tissue Location Highly and constitutively expressed in activated natural killer (NK) cells | |
GZMM Antibody (Center) - Related products
AP6792c: GZMM Antibody (Center)
DC05498: Human GZMM cDNA Clone
LY11981a: GZMM Over-expression Lysate
GZMM Antibody (Center) - Application data
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Western blot analysis of GZMM Antibody (Center) (Cat. #AP6792c) in K562 cell line lysates (35ug/lane). GZMM (arrow) was detected using the purified Pab.
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GZMM Antibody (Center) (Cat. #AP6792c) IHC analysis in formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GZMM Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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GZMM Antibody (Center) (Cat. #AP6792c) flow cytometric analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
GZMM Antibody (Center) - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GZMM cleaves peptide substrates after methionine, leucine, and norleucine.
REFERENCES
Mahrus,S., et.al., J. Biol. Chem. 279 (52), 54275-54282 (2004)
