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GZMM Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GZMM Antibody (Center) AP6792C
    Western blot analysis of GZMM Antibody (Center) (Cat. #AP6792c) in K562 cell line lysates (35ug/lane). GZMM (arrow) was detected using the purified Pab.
  • IHC-P - GZMM Antibody (Center) AP6792C
    GZMM Antibody (Center) (Cat. #AP6792c) IHC analysis in formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GZMM Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - GZMM Antibody (Center) AP6792C
    GZMM Antibody (Center) (Cat. #AP6792c) flow cytometric analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51124
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 27545 Da
Antigen Region 84-113 aa
Additional Information
Gene ID 3004
Other Names Granzyme M, 3421-, Met-1 serine protease, Hu-Met-1, Met-ase, Natural killer cell granular protease, GZMM, MET1
Target/Specificity This GZMM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-113 amino acids from the Central region of human GZMM.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGZMM Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MET1
Function Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
Cellular Location Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes
Tissue Location Highly and constitutively expressed in activated natural killer (NK) cells
Research Areas
Citations (0)

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GZMM cleaves peptide substrates after methionine, leucine, and norleucine.


Mahrus,S.,, J. Biol. Chem. 279 (52), 54275-54282 (2004)

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Cat# AP6792C
(40 western blots)
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