|Application ||WB, IHC-P, FC, E|
|Calculated MW||27545 Da|
|Antigen Region||84-113 aa|
|Other Names||Granzyme M, 3421-, Met-1 serine protease, Hu-Met-1, Met-ase, Natural killer cell granular protease, GZMM, MET1|
|Target/Specificity||This GZMM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-113 amino acids from the Central region of human GZMM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GZMM Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.|
|Cellular Location||Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes|
|Tissue Location||Highly and constitutively expressed in activated natural killer (NK) cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
GZMM cleaves peptide substrates after methionine, leucine, and norleucine.
Mahrus,S., et.al., J. Biol. Chem. 279 (52), 54275-54282 (2004)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.