|Application ||WB, IHC-P, FC, E|
|Calculated MW||27545 Da|
|Antigen Region||84-113 aa|
|Other Names||Granzyme M, 3421-, Met-1 serine protease, Hu-Met-1, Met-ase, Natural killer cell granular protease, GZMM, MET1|
|Target/Specificity||This GZMM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-113 amino acids from the Central region of human GZMM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GZMM Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.|
|Cellular Location||Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes|
|Tissue Location||Highly and constitutively expressed in activated natural killer (NK) cells|
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Provided below are standard protocols that you may find useful for product applications.
GZMM cleaves peptide substrates after methionine, leucine, and norleucine.
Mahrus,S., et.al., J. Biol. Chem. 279 (52), 54275-54282 (2004)
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