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GZMM Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P51124 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 27545 Da |
| Antigen Region | 84-113 aa |
| Gene ID | 3004 |
|---|---|
| Other Names | Granzyme M, 3421-, Met-1 serine protease, Hu-Met-1, Met-ase, Natural killer cell granular protease, GZMM, MET1 |
| Target/Specificity | This GZMM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-113 amino acids from the Central region of human GZMM. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GZMM Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GZMM |
|---|---|
| Synonyms | MET1 |
| Function | Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. |
| Cellular Location | Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes |
| Tissue Location | Highly and constitutively expressed in activated natural killer (NK) cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GZMM cleaves peptide substrates after methionine, leucine, and norleucine.
References
Mahrus,S., et.al., J. Biol. Chem. 279 (52), 54275-54282 (2004)
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