|Application ||WB, IHC-P, E|
|Calculated MW||70941 Da|
|Antigen Region||246-274 aa|
|Other Names||Secretogranin-2, Chromogranin-C, Secretogranin II, SgII, Secretoneurin, SN, SCG2, CHGC|
|Target/Specificity||This Chromogranin-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 246-274 amino acids from the Central region of human Chromogranin-C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Chromogranin-C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides.|
|Cellular Location||Secreted. Note=Neuroendocrine and endocrine secretory granules|
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Provided below are standard protocols that you may find useful for product applications.
Chromogranin-C is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown.
Li,L., et.al., Cell Death Differ. 15 (5), 879-888 (2008)
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