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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > ALKBH8 Antibody (C-term)
ALKBH8 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q96BT7 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 75208 Da |
| Antigen Region | 494-523 aa |
| Gene ID | 91801 |
|---|---|
| Other Names | Alkylated DNA repair protein alkB homolog 8, 11411-, Probable alpha-ketoglutarate-dependent dioxygenase ABH8, S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8, tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8, ALKBH8, ABH8 |
| Target/Specificity | This ALKBH8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 494-523 amino acids from the C-terminal region of human ALKBH8. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ALKBH8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ALKBH8 |
|---|---|
| Synonyms | ABH8 |
| Function | Catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)- methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). |
| Cellular Location | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic |
| Tissue Location | Widely expressed, with highest expression in spleen, followed by pancreas and lung. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
ALKBH8 may inhibit apoptosis and promote cell survival and angiogenesis.
References
Shimada,K., et.al., Cancer Res. 69 (7), 3157-3164 (2009)
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$ 365.00
$ 140.00
Cat# AP6801b
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