|Application ||WB, IHC-P, FC, E|
|Other Accession||A1L131, Q9CXX9, Q3ZBN4|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||32009 Da|
|Antigen Region||239-267 aa|
|Other Names||CUE domain-containing protein 2, CUEDC2, C10orf66|
|Target/Specificity||This CUEDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-267 amino acids from the C-terminal region of human CUEDC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CUEDC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors|
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Provided below are standard protocols that you may find useful for product applications.
CUEDC2 controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.
Grupe,A., et.al., Am. J. Hum. Genet. 78 (1), 78-88 (2006)
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