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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CUEDC2 Antibody (C-term)   

CUEDC2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CUEDC2 Antibody (C-term) AP6803b
    Western blot analysis of CUEDC2 Antibody (C-term) (Cat. #AP6803b) in Y79 cell line lysates (35ug/lane). CUEDC2 (arrow) was detected using the purified Pab.
  • IHC-P - CUEDC2 Antibody (C-term) AP6803b
    Formalin-fixed and paraffin-embedded human brain with CUEDC2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - CUEDC2 Antibody (C-term) AP6803b
    Flow cytometric analysis of hela cells using CUEDC2 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H467
Other Accession A1L131, Q9CXX9, Q3ZBN4
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 32009 Da
Antigen Region 239-267 aa
Additional Information
Gene ID 79004
Other Names CUE domain-containing protein 2, CUEDC2, C10orf66
Target/Specificity This CUEDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-267 amino acids from the C-terminal region of human CUEDC2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCUEDC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C10orf66
Function Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
Cellular Location Cytoplasm. Nucleus
Tissue Location Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors
Research Areas
Citations (0)

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CUEDC2 controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.


Grupe,A.,, Am. J. Hum. Genet. 78 (1), 78-88 (2006)

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$ 295.00
$ 99.00
Cat# AP6803b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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