|Application ||WB, IHC-P, FC, E|
|Calculated MW||45734 Da|
|Antigen Region||273-300 aa|
|Other Names||Arylacetamide deacetylase, AADAC, DAC|
|Target/Specificity||This AADAC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-300 amino acids from the C-terminal region of human AADAC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AADAC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein|
|Tissue Location||Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder.|
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Provided below are standard protocols that you may find useful for product applications.
Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
Saito,S., et.al., J. Hum. Genet. 48 (5), 249-270 (2003)
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