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AADAC Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP6805b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
AADAC Antibody (C-term) - Product info | |
| Application | WB, IHC, FC
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| Primary Accession | P22760 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 45734 Da |
AADAC Antibody (C-term) - Additional info | |
| Gene ID 13 | |
| Other Names AADAC; DAC; Arylacetamide deacetylase | |
| Target/Specificity This AADAC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 279~309 amino acids from the C-terminal region of human AADAC. | |
| Dilution WB~~1:50~100WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AADAC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AADAC Antibody (C-term) - Protein Information | |
| Name AADAC | |
| Synonyms DAC | |
| Function Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionally causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores | |
| Cellular Location Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein | |
| Tissue Location Mainly expressed in liver, small intestine, colon and adrenal gland | |
AADAC Antibody (C-term) - Related products
AP6805b: AADAC Antibody (C-term)
RI10002: AADAC predesign siRNA
DC06353: Human AADAC cDNA Clone
AADAC Antibody (C-term) - Application data
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Western blot analysis of AADAC Antibody (C-term) (Cat. #AP6805b) in 293 cell line lysates (35ug/lane). AADAC (arrow) was detected using the purified Pab.
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Formalin-fixed and paraffin-embedded human hepatocarcinoma with AADAC Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Flow cytometric analysis of widr cells using AADAC Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Western blot analysis of AADAC (arrow) using rabbit polyclonal AADAC Antibody (C-term) (Cat. #AP6805b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the AADAC gene.
AADAC Antibody (C-term) - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
REFERENCES
Saito,S., et.al., J. Hum. Genet. 48 (5), 249-270 (2003)
