|Application ||WB, IHC-P, FC, E|
|Other Accession||P42893, Q4PZA2, P42891|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||87164 Da|
|Antigen Region||528-556 aa|
|Other Names||Endothelin-converting enzyme 1, ECE-1, ECE1|
|Target/Specificity||This ECE-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 528-556 amino acids of human ECE-1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ECE-1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Converts big endothelin-1 to endothelin-1.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ECE-1 is involved in proteolytic processing of endothelin precursors to biologically active peptides.
Cottrell,G.S., et.al., J. Biol. Chem. 284 (33), 22411-22425 (2009)
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