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ECE-1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P42892 |
| Other Accession | P42893, Q4PZA2, P42891 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 87164 Da |
| Antigen Region | 392-419 aa |
| Gene ID | 1889 |
|---|---|
| Other Names | Endothelin-converting enzyme 1, ECE-1, ECE1 |
| Target/Specificity | This ECE-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 392-419 amino acids from the Central region of human ECE-1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ECE-1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ECE1 |
|---|---|
| Function | Converts big endothelin-1 to endothelin-1. |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
ECE-1 is involved in proteolytic processing of endothelin precursors to biologically active peptides.
References
Cottrell,G.S., et.al., J. Biol. Chem. 284 (33), 22411-22425 (2009)
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$ 365.00
$ 140.00
Cat# AP6855c
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