|Application ||WB, IHC-P, E|
|Other Accession||P42893, Q4PZA2, P42891|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||87164 Da|
|Antigen Region||391-420 aa|
|Other Names||Endothelin-converting enzyme 1, ECE-1, ECE1|
|Target/Specificity||This ECE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the Central region of human ECE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ECE1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Converts big endothelin-1 to endothelin-1.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ECE-1 is involved in proteolytic processing of endothelin precursors to biologically active peptides.
Cottrell,G.S., et.al., J. Biol. Chem. 284 (33), 22411-22425 (2009)
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