|Application ||WB, IHC-P, FC, IF, E|
|Calculated MW||35735 Da|
|Antigen Region||82-110 aa|
|Other Names||Aspartoacylase, Aminoacylase-2, ACY-2, ASPA, ACY2, ASP|
|Target/Specificity||This ASPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-110 amino acids from the N-terminal region of human ASPA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ASPA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Brain white matter, skeletal muscle, kidney, adrenal glands, lung and liver|
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Provided below are standard protocols that you may find useful for product applications.
ASPA is an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues.
Bitto,E., et.al., Proc. Natl. Acad. Sci. U.S.A. 104 (2), 456-461 (2007)
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