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MAP3K7IP1 Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MAP3K7IP1 Antibody AP6861c
    Western blot analysis of MAP3K7IP1 (arrow) using rabbit polyclonal MAP3K7IP1-pS438 (Cat. #AP6861c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAP3K7IP1 gene (Lane 2) (Origene Technologies).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15750
Other Accession Q8CF89
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 54644 Da
Antigen Region 416-445 aa
Additional Information
Gene ID 10454
Other Names TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1, TAB1, MAP3K7IP1
Target/Specificity This MAP3K7IP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 416-445 amino acids from human MAP3K7IP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAP3K7IP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAB1
Synonyms MAP3K7IP1
Function May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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MAP3K7IP1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.


Arch,R.H.,, Genes Dev. 12 (18), 2821-2830 (1998)
Yamaguchi,K.,, EMBO J. 18 (1), 179-187 (1999)

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Cat# AP6861c
(40 western blots)
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