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UNC5C Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - UNC5C Antibody (Center) AP6919c
    Western blot analysis of UNC5C Antibody (Center) (Cat. #AP6919c) in K562 cell line lysates (35ug/lane). UNC5C (arrow) was detected using the purified Pab.
  • IHC-P - UNC5C Antibody (Center) AP6919c
    Formalin-fixed and paraffin-embedded human brain tissue with UNC5C Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - UNC5C Antibody (Center) AP6919c
    Flow cytometric analysis of K562 cells using UNC5C Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95185
Other Accession Q761X5
Reactivity Human
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 103146 Da
Antigen Region 188-217 aa
Additional Information
Gene ID 8633
Other Names Netrin receptor UNC5C, Protein unc-5 homolog 3, Protein unc-5 homolog C, UNC5C, UNC5H3
Target/Specificity This UNC5C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-217 amino acids from the Central region of human UNC5C.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUNC5C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UNC5C
Synonyms UNC5H3
Function Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung
Research Areas
Citations (0)

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UNC5C belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.


Hibi,K.,, World J Surg 33 (5), 1053-1057 (2009)

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$ 295.00
$ 99.00
Cat# AP6919c
(40 western blots)
Availability: In Stock
Bulk Size
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