TMPRSS3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IF, WB, E |
---|---|
Primary Accession | P57727 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 49405 Da |
Antigen Region | 272-300 aa |
Gene ID | 64699 |
---|---|
Other Names | Transmembrane protease serine 3, 3421-, Serine protease TADG-12, Tumor-associated differentially-expressed gene 12 protein, TMPRSS3, ECHOS1, TADG12 |
Target/Specificity | This TMPRSS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-300 amino acids from the Central region of human TMPRSS3. |
Dilution | IF~~1:10~50 WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TMPRSS3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TMPRSS3 |
---|---|
Synonyms | ECHOS1, TADG12 |
Function | Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein |
Tissue Location | Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas |
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Provided below are standard protocols that you may find useful for product applications.
Background
TMPRSS3 belongs to the serine protease family. This protein contains a serine protease domain, a transmembrane domain, a LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders.
References
Elbracht,M., et.al., J. Med. Genet. 44 (6), E81 (2007)
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