|Application ||WB, FC, E|
|Other Accession||P24854, Q05716|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||27934 Da|
|Antigen Region||66-92 aa|
|Other Names||Insulin-like growth factor-binding protein 4, IBP-4, IGF-binding protein 4, IGFBP-4, IGFBP4, IBP4|
|Target/Specificity||This IGFBP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-92 amino acids from the N-terminal region of human IGFBP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||IGFBP4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|
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Provided below are standard protocols that you may find useful for product applications.
IGFBP4 has an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
Durai,R., et.al., Colorectal Dis 9 (7), 625-631 (2007)
Laursen,L.S., et.al., Mol. Endocrinol. 21 (5), 1246-1257 (2007)
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