|Application ||WB, IHC-P, FC, E|
|Other Accession||Q8BHT7, Q2T9P3|
|Calculated MW||42455 Da|
|Antigen Region||243-271 aa|
|Other Names||RAB6A-GEF complex partner protein 2, Retrograde Golgi transport protein RGP1 homolog, RGP1 (HGNC:21965), KIAA0258|
|Target/Specificity||This RGP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-271 amino acids from the C-terminal region of human RGP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||RGP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors.|
|Cellular Location||Cytoplasm, cytosol. Membrane|
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Provided below are standard protocols that you may find useful for product applications.
Retrograde golgi transport homolog 1 (RGP1) is the mammalian homolog to the yeast RGP1, and is thought to be a potential Golgi recycling factor. The protein forms a tight complex with RIC1 and this complex binds Ypt6p and stimulates guanine nucleotide exchange. RGP1 yeast mutants exhibit defects in retrograde trafficking that are similar to those seen in yeast, with mutations in other retrograde Golgi transport proteins. It is expected that RGP1 plays a similar role in mammalian cells.
Gerhard,D.S., et.al., Genome Res. 14 (10B), 2121-2127 (2004)
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