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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RGP1 Antibody (C-term)   

RGP1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RGP1 Antibody (C-term) AP6957b
    Western blot analysis of RGP1 Antibody (C-term) (Cat. #AP6957b) in mouse heart tissue lysates (35ug/lane). RGP1 (arrow) was detected using the purified Pab.
  • IHC-P - RGP1 Antibody (C-term) AP6957b
    Formalin-fixed and paraffin-embedded human lung carcinoma reacted with RGP1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - RGP1 Antibody (C-term) AP6957b
    RGP1 Antibody (C-term) (Cat. #AP6957b) flow cytometric analysis of NCI-H292 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92546
Other Accession Q8BHT7, Q2T9P3
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 42455 Da
Antigen Region 243-271 aa
Additional Information
Gene ID 9827
Other Names RAB6A-GEF complex partner protein 2, Retrograde Golgi transport protein RGP1 homolog, RGP1 (HGNC:21965), KIAA0258
Target/Specificity This RGP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-271 amino acids from the C-terminal region of human RGP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRGP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGP1 (HGNC:21965)
Synonyms KIAA0258
Function The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors.
Cellular Location Cytoplasm, cytosol. Membrane
Research Areas
Citations (0)

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Retrograde golgi transport homolog 1 (RGP1) is the mammalian homolog to the yeast RGP1, and is thought to be a potential Golgi recycling factor. The protein forms a tight complex with RIC1 and this complex binds Ypt6p and stimulates guanine nucleotide exchange. RGP1 yeast mutants exhibit defects in retrograde trafficking that are similar to those seen in yeast, with mutations in other retrograde Golgi transport proteins. It is expected that RGP1 plays a similar role in mammalian cells.


Gerhard,D.S.,, Genome Res. 14 (10B), 2121-2127 (2004)

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Cat# AP6957b
(40 western blots)
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