|Application ||FC, IHC-P, WB, E|
|Calculated MW||19536 Da|
|Antigen Region||44-73 aa|
|Other Names||Methionine-R-sulfoxide reductase B2, mitochondrial, MsrB2, 184-, MSRB2, CBS-1, MSRB|
|Target/Specificity||This MSRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-73 amino acids from the Central region of human MSRB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MSRB2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.|
|Tissue Location||Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate.|
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Provided below are standard protocols that you may find useful for product applications.
MSRB2 catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine.
Cabreiro,F., et.al., J. Biol. Chem. 283 (24), 16673-16681 (2008)
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