|Application ||FC, IHC-P, WB, E|
|Calculated MW||19536 Da|
|Antigen Region||44-73 aa|
|Other Names||Methionine-R-sulfoxide reductase B2, mitochondrial, MsrB2, 184-, MSRB2, CBS-1, MSRB|
|Target/Specificity||This MSRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-73 amino acids from the Central region of human MSRB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MSRB2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.|
|Tissue Location||Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
MSRB2 catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine.
Cabreiro,F., et.al., J. Biol. Chem. 283 (24), 16673-16681 (2008)
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