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CLEC16A Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CLEC16A Antibody (Center) AP6983c
    Western blot analysis of CLEC16A Antibody (Center) (Cat. #AP6983c) in A2058 cell line lysates (35ug/lane).CLEC16A (arrow) was detected using the purified Pab.
    detail
  • WB - CLEC16A Antibody (Center) AP6983c
    Western blot analysis of CLEC16A Antibody (Center) (Cat. #AP6983c) in mouse brain tissue lysates (35ug/lane).CLEC16A (arrow) was detected using the purified Pab.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q2KHT3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 117715 Da
Antigen Region 365-391 aa
Additional Information
Gene ID 23274
Other Names Protein CLEC16A, C-type lectin domain family 16 member A {ECO:0000312|HGNC:HGNC:29013}, CLEC16A (HGNC:29013), KIAA0350
Target/Specificity This CLEC16A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-391 amino acids from the Central region of human CLEC16A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLEC16A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLEC16A (HGNC:29013)
Synonyms KIAA0350
Function Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
Cellular Location Endosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q80U30}. Lysosome membrane {ECO:0000250|UniProtKB:Q80U30}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q80U30}. Note=Associates with the endolysosome membrane. {ECO:0000250|UniProtKB:Q80U30}
Tissue Location Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells
Research Areas
Citations ( 0 )

Background

CLEC16A is almost exclusively expressed in immune cells, including dendritic cells, B lymphocytes and natural killer cells. There are three isoforms.

References

Hafler,D.A., et.al., N. Engl. J. Med. 357 (9), 851-862 (2007)

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$ 182.50
$ 70.00
Cat# AP6983c
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