|Application ||WB, IHC-P, FC, E|
|Calculated MW||33542 Da|
|Antigen Region||226-254 aa|
|Other Names||Arylamine N-acetyltransferase 2, Arylamide acetylase 2, N-acetyltransferase type 2, NAT-2, Polymorphic arylamine N-acetyltransferase, PNAT, NAT2, AAC2|
|Target/Specificity||This NAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 amino acids from the C-terminal region of human NAT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NAT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.|
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Provided below are standard protocols that you may find useful for product applications.
NAT2 is an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens.
Kim,S.H., et.al., Pharmacogenomics 10 (11), 1767-1779 (2009)
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