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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GRK6 Antibody (C-term)   

GRK6 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GRK6 Antibody (C-term) AP7008a
    Western blot analysis of anti-GRK6 Pab (Cat. #AP7008a) in HeLa cell lysate (Lane 1) and mouse heart tissue lysate (Lane 2). GRK6 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
  • IHC-P - GRK6 Antibody (C-term) AP7008a
    GRK6 Antibody (C-term) (Cat. #AP7008A)immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GRK6 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P43250
Other Accession P97711, O70293
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 65991 Da
Antigen Region 551-576 aa
Additional Information
Gene ID 2870
Other Names G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6, GRK6, GPRK6
Target/Specificity This GRK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-576 amino acids from the C-terminal region of human GRK6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGRK6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRK6
Synonyms GPRK6
Function Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Cellular Location Membrane; Lipid-anchor.
Tissue Location Widely expressed.
Research Areas
Citations (0)

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GRK6 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation.


Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
Stoffel, R.H., et al., J. Biol. Chem. 269(45):27791-27794 (1994).
Benovic, J.L., et al., J. Biol. Chem. 268(26):19521-19527 (1993).

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$ 295.00
$ 99.00
Cat# AP7008a
(40 western blots)
Availability: In Stock
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