|Application ||WB, IHC-P, E|
|Other Accession||P97711, O70293|
|Calculated MW||65991 Da|
|Antigen Region||551-576 aa|
|Other Names||G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6, GRK6, GPRK6|
|Target/Specificity||This GRK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-576 amino acids from the C-terminal region of human GRK6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GRK6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).|
|Cellular Location||Membrane; Lipid-anchor.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
GRK6 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation.
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
Stoffel, R.H., et al., J. Biol. Chem. 269(45):27791-27794 (1994).
Benovic, J.L., et al., J. Biol. Chem. 268(26):19521-19527 (1993).
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