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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   JIK (TAOK3) Antibody (C-term)   

JIK (TAOK3) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - JIK (TAOK3) Antibody (C-term) AP7012b
    Western blot analysis of TAOK3 (arrow) using rabbit polyclonal TAOK3 Antibody (C-term)(Cat.#AP7012b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TAOK3 gene (Lane 2) (Origene Technologies).
  • IHC-P - JIK (TAOK3) Antibody (C-term) AP7012b
    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with TAOK3 antibody (C-term)(Cat.#AP7012b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H2K8
Other Accession Q6DD27, Q53UA7, Q8BYC6, Q9I9E0
Reactivity Human
Predicted Chicken, Mouse, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 105406 Da
Antigen Region 671-700 aa
Additional Information
Gene ID 51347
Other Names Serine/threonine-protein kinase TAO3, Cutaneous T-cell lymphoma-associated antigen HD-CL-09, CTCL-associated antigen HD-CL-09, Dendritic cell-derived protein kinase, JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, hKFC-A, Thousand and one amino acid protein 3, TAOK3, DPK, JIK, KDS, MAP3K18
Target/Specificity This JIK (TAOK3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 671-700 amino acids from the C-terminal region of human JIK (TAOK3).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsJIK (TAOK3) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAOK3
Synonyms DPK, JIK, KDS, MAP3K18
Function Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to the peripheral cell membrane
Tissue Location Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver
Research Areas
Citations (0)

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TAOK3 is negatively regulated by epidermal growth factor (EGF) and Inhibits the basal activity of Jun kinase. When TAOK3 is overexpressed, it may activate ERK1/ERK2 and JNK/SAPK.


Hartmann,T.B.,Br. J. Dermatol. 150 (2), 252-258 (2004)
Yustein,J.T.,Oncogene 22 (40), 6129-6141 (2003)
Yoneda,T.,J. Biol. Chem. 276 (17), 13935-13940 (2001)
Zhang,W.,Biochem. Biophys. Res. Commun. 274 (3), 872-879 (2000)

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$ 295.00
$ 99.00
Cat# AP7012b
(40 western blots)
Availability: In Stock
Bulk Size
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