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SCYL2 Antibody(C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q6P3W7 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 103709 Da |
| Antigen Region | 643-672 aa |
| Gene ID | 55681 |
|---|---|
| Other Names | SCY1-like protein 2, Coated vesicle-associated kinase of 104 kDa, SCYL2, CVAK104, KIAA1360 |
| Target/Specificity | This SCYL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 643-672 amino acids from the C-terminal region of human SCYL2. |
| Dilution | IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SCYL2 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SCYL2 (HGNC:19286) |
|---|---|
| Function | Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (PubMed:15809293, PubMed:16914521). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (By similarity). |
| Cellular Location | Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane Endosome membrane. Note=Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes |
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Provided below are standard protocols that you may find useful for product applications.
Background
SCYL2 is a component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. SCYL2 is a probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. SCYL2 may also regulate clathrin-dependent trafficking between the TGN and/or the endosomal system.
References
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
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