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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PDK3 Antibody   

PDK3 Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PDK3 Antibody AP7040d
    Western blot analysis of PDK3 Antibody (Cat. #AP7040d) in MCF-7 cell line lysates (35ug/lane). PDK3 (arrow) was detected using the purified Pab.
  • FC - PDK3 Antibody AP7040d
    PDK3 Antibody (Cat.#AP7040d) FC analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15120
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46939 Da
Additional Information
Gene ID 5165
Other Names [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial, Pyruvate dehydrogenase kinase isoform 3, PDK3, PDHK3
Target/Specificity This PDK3 antibody is generated from rabbits immunized with human PDK3 recombinant protein.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDK3
Synonyms PDHK3
Function Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.
Cellular Location Mitochondrion matrix.
Tissue Location Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain
Research Areas
Citations ( 0 )


PDK3 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.


Baker, J.C., et al., J. Biol. Chem. 275(21):15773-15781 (2000).
Gudi, R., et al., J. Biol. Chem. 270(48):28989-28994 (1995).

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$ 295.00
$ 99.00
Cat# AP7040d
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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