|Application ||WB, IHC-P, E|
|Calculated MW||61830 Da|
|Antigen Region||1-30 aa|
|Other Names||Pyruvate kinase PKLR, Pyruvate kinase 1, Pyruvate kinase isozymes L/R, R-type/L-type pyruvate kinase, Red cell/liver pyruvate kinase, PKLR, PK1, PKL|
|Target/Specificity||This PKLR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PKLR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PKLR Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a key role in glycolysis.|
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Provided below are standard protocols that you may find useful for product applications.
PKLR is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA).
Wang, H., et al., Diabetes 51(9):2861-2865 (2002). Valentini, G., et al., J. Biol. Chem. 277(26):23807-23814 (2002). Mateu, E., et al., Hum. Genet. 110(6):532-544 (2002). Indo, Y., et al., Hum. Mutat. 18(4):308-318 (2001). Acan, N.L., et al., J. Enzym. Inhib. 16(5):457-464 (2001).
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