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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Deoxyguanosine Kinase (DGUOK) Antibody (N-term)   

Deoxyguanosine Kinase (DGUOK) Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Deoxyguanosine Kinase (DGUOK) Antibody (N-term) AP7086A
    Western blot analysis of anti-hDGUOK-M1 Pab (Cat. #AP7086a) in 293 cell line lysate (35ug/lane). hDGUOK-M1(arrow) was detected using the purified Pab.
  • WB - Deoxyguanosine Kinase (DGUOK) Antibody (N-term) AP7086A
    Western blot analysis of anti-DGUOK Pab (Cat. #AP7086a) in mouse kidney tissue lysate (35ug/lane). DGUOK(arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16854
Other Accession NP_550438
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 32056 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 1716
Other Names Deoxyguanosine kinase, mitochondrial, dGK, DGUOK, DGK
Target/Specificity This Deoxyguanosine Kinase (DGUOK) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human Deoxyguanosine Kinase (DGUOK).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDeoxyguanosine Kinase (DGUOK) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DGK
Function Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Cellular Location Mitochondrion.
Tissue Location Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues.
Research Areas
Citations (0)

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Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Mitochondrial DNA depletion syndromes are phenotypically heterogeneous, autosomal recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of mtDNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.

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Cat# AP7086A
(40 western blots)
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