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Activin Receptor Type IA (ACVR1) Antibody (Center N99)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP7101c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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Activin Receptor Type IA (ACVR1) Antibody (Center N99) - Product info | |
| Application | WB
|
| Primary Accession | Q04771 |
| Other Accession | P37172, Q28041 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 57153 Da |
Activin Receptor Type IA (ACVR1) Antibody (Center N99) - Additional info | |
| Gene ID 90 | |
| Other Names ACVR1; ACVRLK2; Activin receptor type-1; Activin receptor type I; Activin receptor-like kinase 2; Serine/threonine-protein kinase receptor R1; TGF-B superfamily receptor type I | |
| Target/Specificity This ACVR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human ACVR1. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Activin Receptor Type IA (ACVR1) Antibody (Center N99) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Activin Receptor Type IA (ACVR1) Antibody (Center N99) - Protein Information | |
| Name ACVR1 | |
| Synonyms ACVRLK2 | |
| Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity) | |
| Cellular Location Membrane; Single-pass type I membrane protein | |
| Tissue Location Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells | |
Activin Receptor Type IA (ACVR1) Antibody (Center N99) - Related products
AP13856c: ACVR1 Antibody (Center)
AP7101a: Activin Receptor Type IA (ACVR1) Antibody (Center N153)
AP7101b: Activin Receptor Type IA (ACVR1) Antibody (N-term)
AP7101c: Activin Receptor Type IA (ACVR1) Antibody (Center N99)
AP7806c: Activin Receptor Type IA (ACVR1) Antibody (Center R147)
RI10097: ACVR1 predesign siRNA
DC06679: Human ACVR1 cDNA Clone
LY10656a: ACVR1 Over-expression Lysate
BP7101a: ACVR1 Antibody (Center N153) Blocking Peptide
BP7101b: ACVR1 Antibody (N-term) Blocking Peptide
BP7101c: ACVR1 Antibody (Center N99) Blocking Peptide
Activin Receptor Type IA (ACVR1) Antibody (Center N99) - Application data
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Western blot analysis of anti-ACVR1 Pab (Cat. #AP7101c) in mouse brain tissue lysate. ACVR1(arrow) was detected using the purified Pab.
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ACVR1 Antibody (N-term) (Cat. #AP7101c) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the ACVR1 antibody detected the ACVR1 protein (arrow).
Activin Receptor Type IA (ACVR1) Antibody (Center N99) - Research Areas
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BACKGROUND
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is an activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.
REFERENCES
Kan, L. et al. Stem Cells. January; 27(1): 150?56(2009). Casagrandi, D., et al., Mol. Hum. Reprod. 9(4):199-203 (2003). Welt, C.K., Curr Opin Obstet Gynecol 14(3):317-323 (2002). Schneider-Kolsky, M.E., et al., Placenta 23(4):294-302 (2002). Chapman, S.C., et al., Mol. Endocrinol. 15(4):668-679 (2001). Schulte, K.M., et al., Horm. Metab. Res. 32(10):390-400 (2000).
