- Antibodies
- New
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Tag
- Peptides
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Amino Acids
- Tag
- Biological Process >
- Proteins
- RNAi
- FL cDNA Clones
- Cell/Tissues/Lysates
Activin A Receptor Type IC (ACVR1C) Antibody (Center)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
Australia Austria Belgium Brazil Bulgaria Canada China Croatia Cyprus Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland India Indonesia Ireland Israel Italy Japan Korea Latvia Lithuania Luxembourg Macedonia Malaysia Malta Netherlands Norway Pakistan Poland Portugal Romania Serbia Singapore Slovakia Slovenia Spain Sweden Switzerland Taiwan Turkey United Kingdom United States Vietnam Others 
|
|||
|---|---|---|---|---|
| Catalog # | Size | Availability | Price | |
| AP7102b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
Activin A Receptor Type IC (ACVR1C) Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | Q8NER5 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 54871 Da |
Activin A Receptor Type IC (ACVR1C) Antibody (Center) - Additional info | |
| Gene ID 130399 | |
| Other Names ACVR1C; ALK7; Activin receptor type-1C; Activin receptor type IC; Activin receptor-like kinase 7 | |
| Target/Specificity This ACVR1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human ACVR1C. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Activin A Receptor Type IC (ACVR1C) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Activin A Receptor Type IC (ACVR1C) Antibody (Center) - Protein Information | |
| Name ACVR1C | |
| Synonyms ALK7 | |
| Function Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis | |
| Cellular Location Membrane; Single-pass type I membrane protein | |
| Tissue Location Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy | |
Activin A Receptor Type IC (ACVR1C) Antibody (Center) - Related products
AP7102a: Activin A Receptor Type IC (ACVR1C) Antibody (N-term A48)
AP7102b: Activin A Receptor Type IC (ACVR1C) Antibody (Center)
AP7102c: ACVR1C Antibody (Center E271)
RI10099: ACVR1C predesign siRNA
DC05296: Human ACVR1C cDNA Clone
BP7102a: ACVR1C Antibody (N-term A48) Blocking Peptide
Activin A Receptor Type IC (ACVR1C) Antibody (Center) - Application data
-
Western blot analysis of Activin A Receptor Type IC (ACVR1C) antibody (Center)(Cat. #AP7102b) in mouse cerebellum tissue lysates (35ug/lane). ACVR1C (arrow) was detected using the purified Pab.
Activin A Receptor Type IC (ACVR1C) Antibody (Center) - Research Areas
Abgent welcomes feedback from its customers.
If you have used an Abgent product and would like to share how it has performed, please click on the
"Submit Review" button and provide the requested information. Our staff will examine and post your
review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.
Thank you for your support.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.
REFERENCES
Munir, S., et al., J. Biol. Chem. 279(30):31277-31286 (2004). Kim, B.C., et al., J. Biol. Chem. 279(27):28458-28465 (2004). Roberts, H.J., et al., Biol. Reprod. 68(5):1719-1726 (2003). Tsuchida, K., et al., Mol. Cell. Endocrinol. 220 (1-2), 59-65 (2004) (): (). Bondestam, J., et al., Cytogenet. Cell Genet. 95 (3-4), 157-162 (2001) (): ().
