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ALS2CR2 Antibody (C-term L289)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP7110d | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ALS2CR2 Antibody (C-term L289) - Product info | |
| Application | WB
|
| Primary Accession | Q9C0K7 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 47026 Da |
ALS2CR2 Antibody (C-term L289) - Additional info | |
| Gene ID 55437 | |
| Other Names STRADB; ALS2CR2; ILPIP; STE20-related kinase adapter protein beta; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein; Pseudokinase ALS2CR2 | |
| Target/Specificity This ALS2CR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281~311 amino acids from the C-terminal region of human ALS2CR2. | |
| Dilution WB~~1:50~100WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ALS2CR2 Antibody (C-term L289) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ALS2CR2 Antibody (C-term L289) - Protein Information | |
| Name STRADB | |
| Synonyms ALS2CR2, ILPIP | |
| Function Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity) | |
| Cellular Location Nucleus. Cytoplasm. | |
| Tissue Location Highly expressed in heart, skeletal muscle, testis, liver and colon | |
ALS2CR2 Antibody (C-term L289) - Related products
AP7110a: ALS2CR2 Antibody (N-term)
AP7110b: ALS2CR2 Antibody (C-term)
AP7110d: ALS2CR2 Antibody (C-term L289)
AP7110e: ALS2CR2 Antibody (N-term)
RI15146: STRADB predesign siRNA
DC02366: Human STRADB cDNA Clone
LY10372a: ALS2CR2 Over-expression Lysate
BP7110a: ALS2CR2 Antibody (N-term) Blocking Peptide
BP7110b: ALS2CR2 Antibody (C-term) Blocking Peptide
BP7110d: ALS2CR2 Antibody (C-term L289) Blocking Peptide
ALS2CR2 Antibody (C-term L289) - Application data
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Western blot analysis of ALS2CR2 (arrow) using ALS2CR2 Antibody (C-term L289) (Cat.#AP7110d). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ALS2CR2 gene (Lane 2) (Origene Technologies).
ALS2CR2 Antibody (C-term L289) - Research Areas
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BACKGROUND
ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2.
REFERENCES
Nishigaki, K., et al., J. Biol. Chem. 278(15):13520-13530 (2003). Sanna, M.G., et al., J. Biol. Chem. 277(34):30454-30462 (2002). Hadano, S., et al., Genomics 71(2):200-213 (2001).
