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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AMHR2 Antibody (C-term)   

AMHR2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - AMHR2 Antibody (C-term) AP7111c
    Western blot analysis of AMHR2 Antibody (C-term) (Cat. #AP7111c) in CEM cell line lysates (35ug/lane).AMHR2 (arrow) was detected using the purified Pab.
  • FC - AMHR2 Antibody (C-term) AP7111c
    Flow cytometric analysis of CEM cells using AMHR2 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • WB - AMHR2 Antibody (C-term) AP7111c
    Western blot analysis of AMHR2 Antibody (C-term) (Cat. #AP7111c) in CEM cell line lysates (35ug/lane).AMHR2 (arrow) was detected using the purified Pab.
  • FC - AMHR2 Antibody (C-term) AP7111c
    Flow cytometric analysis of CEM cells using AMHR2 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • SPECIFICATION
  • CITATIONS: 1
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q16671
Other Accession Q62893, Q8K592
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 62750 Da
Antigen Region 374-402 aa
Additional Information
Gene ID 269
Other Names Anti-Muellerian hormone type-2 receptor, Anti-Muellerian hormone type II receptor, AMH type II receptor, MIS type II receptor, MISRII, MRII, AMHR2, AMHR, MISR2
Target/Specificity This AMHR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-402 amino acids from the C-terminal region of human AMHR2.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAMHR2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AMHR2
Synonyms AMHR, MISR2
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations ( 0 )

Background

The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.

References

Picard, J.Y., et al., J. Soc. Biol. 196(3):217-221 (2002).
Teixeira, J., et al., Endocr. Rev. 22(5):657-674 (2001).
Imbeaud, S., et al., Nat. Genet. 11(4):382-388 (1995).
Visser, J.A., et al., Biochem. Biophys. Res. Commun. 215(3):1029-1036 (1995).
Sinisi, A.A., et al., J. Endocrinol. Invest. 26 (3 Suppl), 23-28 (2003).

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$ 295.00
$ 99.00
Cat# AP7111c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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