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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CAMKK2 Antibody (N-term G67)   

CAMKK2 Antibody (N-term G67)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CAMKK2 Antibody (N-term G67) AP7117d
    Western blot analysis of CAMKK2 (arrow) using rabbit polyclonal CAMKK2 Antibody (N-term G67) (Cat.#AP7117d). 293 cell lysates (2 ug/lane) either nontransfected (c) or transiently transfected with the CAMKK2 gene (Lane 2) (Origene Technologies).
  • IHC-P - CAMKK2 Antibody (N-term G67) AP7117d
    Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with CAMKK2 antibody (N-term) (Cat.#AP7117d), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96RR4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 64746 Da
Antigen Region 52-82 aa
Additional Information
Gene ID 10645
Other Names Calcium/calmodulin-dependent protein kinase kinase 2, CaM-KK 2, CaM-kinase kinase 2, CaMKK 2, Calcium/calmodulin-dependent protein kinase kinase beta, CaM-KK beta, CaM-kinase kinase beta, CaMKK beta, CAMKK2, CAMKKB, KIAA0787
Target/Specificity This CAMKK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-82 amino acids from the N-terminal region of human CAMKK2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCAMKK2 Antibody (N-term G67) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CAMKKB, KIAA0787
Function Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin- binding domain are inactive. Efficiently phosphorylates 5'-AMP- activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Cellular Location Nucleus. Cytoplasm. Cell projection. Note=Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction.
Tissue Location Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung
Research Areas
Citations (0)

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CAMKK2 belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. CAMKK2 appears to be involved in hippocampal activation of CREB1.


Hsu, L.S., et al., J. Biol. Chem. 276(33):31113-31123 (2001).
Hsu, L.S., et al., J. Biomed. Sci. 5(2):141-149 (1998).
Anderson, K.A., et al., J. Biol. Chem. 273(48):31880-31889 (1998).
Ishikawa, Y., et al., FEBS Lett. 550 (1-3), 57-63 (2003)

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Cat# AP7117d
(40 western blots)
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