|Application ||WB, E|
|Calculated MW||102480 Da|
|Antigen Region||39-72 aa|
|Other Names||Serine/threonine-protein kinase/endoribonuclease IRE2, Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, hIRE2p, Ire1-beta, IRE1b, Serine/threonine-protein kinase, Endoribonuclease, 3126-, ERN2 (HGNC:16942)|
|Target/Specificity||This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-72 amino acids from the N-terminal region of human ERN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ERN2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.
Iwawaki, T., et al., Nat. Cell Biol. 3(2):158-164 (2001).
Niwa, M., et al., Cell 99(7):691-702 (1999).
Wang, X.Z., et al., EMBO J. 17(19):5708-5717 (1998).
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