|Application ||IHC-P, E|
|Calculated MW||81750 Da|
|Antigen Region||105-136 aa|
|Other Names||Guanylate cyclase soluble subunit alpha-2, GCS-alpha-2, GUCY1A2, GUC1A2, GUCSA2|
|Target/Specificity||This Guanylyl Cyclase alpha 2 (GUCY1A2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-136 amino acids from the N-terminal region of human Guanylyl Cyclase alpha 2 (GUCY1A2).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Guanylyl Cyclase alpha 2 (GUCY1A2) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has guanylyl cyclase on binding to the beta-1 subunit.|
|Tissue Location||Isoform 1 is expressed in fetal brain, liver, colon, endothelium and testis. Isoform 2 is expressed only in liver, colon and endothelium|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
Baba, H., et al., Neuroreport 15(4):677-680 (2004).
Bellamy, T.C., et al., Proc. Natl. Acad. Sci. U.S.A. 99(1):507-510 (2002).
Russwurm, M., et al., J. Biol. Chem. 276(48):44647-44652 (2001).
Bamberger, A.M., et al., J. Clin. Endocrinol. Metab. 86(2):909-912 (2001).
Budworth, J., et al., Biochem. Biophys. Res. Commun. 263(3):696-701 (1999).
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