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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MNK2 (MKNK2) Antibody (C-term)   

MNK2 (MKNK2) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MNK2 (MKNK2) Antibody (C-term) AP7152a
    Anti-MKNK2 Antibody (C-term) at 1:1000 dilution + Hela whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 52 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - MNK2 (MKNK2) Antibody (C-term) AP7152a
    Western blot analysis of MNK2 (MKNK2) antibody (C-term) (Cat.# AP7152a) in 293 cell line lysates (35ug/lane). MNK2 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HBH9
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51875 Da
Antigen Region 402-432 aa
Additional Information
Gene ID 2872
Other Names MAP kinase-interacting serine/threonine-protein kinase 2, MAP kinase signal-integrating kinase 2, MAPK signal-integrating kinase 2, Mnk2, MKNK2, GPRK7, MNK2
Target/Specificity This MNK2 (MKNK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-432 amino acids from the C-terminal region of human MNK2 (MKNK2).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMNK2 (MKNK2) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MKNK2
Synonyms GPRK7, MNK2
Function Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
Cellular Location Isoform 2: Nucleus, PML body.
Tissue Location Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1.
Research Areas
Citations (0)

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MKNK2 may play a role in the response to environmental stress and cytokines. This protein appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.


Scheper, G.C., et al., Mol. Cell. Biol. 23(16):5692-5705 (2003). Knauf, U., et al., Mol. Cell. Biol. 21(16):5500-5511 (2001). Scheper, G.C., et al., Mol. Cell. Biol. 21(3):743-754 (2001). Slentz-Kesler, K., et al., Genomics 69(1):63-71 (2000). Haribabu, B., et al., Proc. Natl. Acad. Sci. U.S.A. 90(20):9398-9402 (1993).

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$ 295.00
$ 99.00
Cat# AP7152a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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