PANK3 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q9H999 |
Other Accession | Q8R2W9, Q08DA5 |
Reactivity | Human |
Predicted | Bovine, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 41094 Da |
Antigen Region | 1-30 aa |
Gene ID | 79646 |
---|---|
Other Names | Pantothenate kinase 3, hPanK3, Pantothenic acid kinase 3, PANK3 |
Target/Specificity | This PANK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PANK3. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PANK3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PANK3 |
---|---|
Function | Catalyzes the phosphorylation of pantothenate to generate 4'- phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. |
Cellular Location | Cytoplasm {ECO:0000269|PubMed:23152917, ECO:0000305} |
Tissue Location | Highly expressed in the liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PANK3 belongs to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver.
References
Zhou, B., et al., Nat. Genet. 28(4):345-349 (2001).
Robishaw, J.D., et al., Am. J. Physiol. 248 (1 PT 1), E1-E9 (1985) (): ().
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