- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||237136 Da|
|Antigen Region||1531-1561 aa|
|Other Names||1-phosphatidylinositol 3-phosphate 5-kinase, Phosphatidylinositol 3-phosphate 5-kinase, FYVE finger-containing phosphoinositide kinase, PIKfyve, Phosphatidylinositol 3-phosphate 5-kinase type III, PIPkin-III, Type III PIP kinase, PIKFYVE, KIAA0981, PIP5K3|
|Target/Specificity||This PIP5K3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1561 amino acids from the Central region of human PIP5K3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||PIP5K3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.|
|Cellular Location||Endosome membrane Note=Mainly associated with membranes of the late endocytic pathway|
Provided below are standard protocols that you may find useful for product applications.
PIP5K3 belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. Signaling by phosphorylated species of phosphatidylinositol regulates diverse cellular processes, including membrane trafficking and cytoskeletal reorganization.
Sbrissa, D., et al., Mol. Cell. Biol. 24(23):10437-10447 (2004).
Yang, S.A., et al., J. Biol. Chem. 279(40):42331-42336 (2004).
Ikonomov, O.C., et al., J. Biol. Chem. 278(51):50863-50871 (2003).
Ikonomov, O.C., et al., Mol. Biol. Cell 14(11):4581-4591 (2003).
Sbrissa, D., et al., J. Biol. Chem. 277(8):6073-6079 (2002).
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