- CITATIONS: 1
|Application ||WB, E|
|Calculated MW||39548 Da|
|Antigen Region||320-349 aa|
|Other Names||Twinfilin-2, A6-related protein, hA6RP, Protein tyrosine kinase 9-like, Twinfilin-1-like protein, TWF2, PTK9L|
|Target/Specificity||This Twinfilin-2 (PTK9L) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-349 amino acids from the C-terminal region of human Twinfilin-2 (PTK9L).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Twinfilin-2 (PTK9L) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, stereocilium. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization|
|Tissue Location||Ubiquitously expressed (at protein level).|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein.
Rohwer, A., et al., Eur. J. Biochem. 263(2):518-525 (1999).
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