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AKR7A2 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - AKR7A2 Antibody (N-term) AP7186a
    Western blot analysis of anti-AKR7A2 antibody (N-term) (Cat. #AP7186a) in 293 cell line lysates (35ug/lane). AKR7A2 (arrow) was detected using the purified Pab. Western blot analysis of anti-AKR7A2 Antibody (N-term) (Cat. #AP7186a) in mouse liver tissue lysates (35ug/lane). AKR7A2 (arrow) was detected using the purified Pab .
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43488
Other Accession Q8NHP1, Q8CG45
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 39589 Da
Antigen Region 101-129 aa
Additional Information
Gene ID 8574
Other Names Aflatoxin B1 aldehyde reductase member 2, 111n11, AFB1 aldehyde reductase 1, AFB1-AR 1, Aldoketoreductase 7, Succinic semialdehyde reductase, SSA reductase, AKR7A2, AFAR, AFAR1, AKR7
Target/Specificity This AKR7A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-129 amino acids from the N-terminal region of human AKR7A2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAKR7A2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKR7A2
Synonyms AFAR, AFAR1, AKR7
Function Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Cellular Location Golgi apparatus. Cytoplasm
Tissue Location Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts Detected at low levels in lung and pancreas (at protein level) Widely expressed.
Research Areas
Citations (0)

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AKR7A2 is aldo-keto reductases, which are involved in the detoxification of aldehydes and ketones.


Ireland L.S., Harrison D.J.Biochem. J. 332:21-34(1998)
Kelly V.P., Sherratt P.J.Biochem. J. 366:847-861(2002)

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$ 295.00
$ 99.00
Cat# AP7186a
(40 western blots)
Availability: In Stock
Bulk Size
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