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HMGB2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - HMGB2 Antibody (Center) AP7195c
    HMGB2 Antibody (Center) (Cat. #AP7195c) western blot analysis in HL-60,K562,H-4-II-E cell line lysates (35ug/lane).This demonstrates the HMGB2 antibody detected the HMGB2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P26583
Other Accession P52925, P17741, P40673
Reactivity Human
Predicted Bovine, Pig, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 24034 Da
Antigen Region 92-118 aa
Additional Information
Gene ID 3148
Other Names High mobility group protein B2, High mobility group protein 2, HMG-2, HMGB2, HMG2
Target/Specificity This HMGB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-118 amino acids from the Central region of human HMGB2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHMGB2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HMGB2
Synonyms HMG2
Function DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity).
Cellular Location Nucleus. Chromosome.
Research Areas
Citations (0)

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HMGB2 is a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.


Majumdar A., Brown D. 19:6643-6643(1991)
Shirakawa H., Yoshida M.J.. 267:6641-6645(1992)
Alexandre S., Li W.W.Nucleic Acids Res. 20:6413-6413(1992)
Fan Z., Beresford P.J.Mol. Cell. Biol. 22:2810-2820(2002)

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$ 295.00
$ 99.00
Cat# AP7195c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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