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PHKG1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q16816 |
| Other Accession | P13286, P00518 |
| Reactivity | Human |
| Predicted | Rabbit, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45024 Da |
| Antigen Region | 302-332 aa |
| Gene ID | 5260 |
|---|---|
| Other Names | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform, PHK-gamma-M, Phosphorylase kinase subunit gamma-1, Serine/threonine-protein kinase PHKG1, PHKG1, PHKG |
| Target/Specificity | This PHKG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-332 amino acids from the Central region of human PHKG1. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PHKG1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PHKG1 |
|---|---|
| Synonyms | PHKG |
| Function | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12.
References
Wehner, M., et al., Hum. Genet. 96(5):616-618 (1995).
Jones, T.A., et al., Biochim. Biophys. Acta 1048(1):24-29 (1990).
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