- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||53087 Da|
|Antigen Region||420-450 aa|
|Other Names||Calcium/calmodulin-dependent protein kinase type 1G, CaM kinase I gamma, CaM kinase IG, CaM-KI gamma, CaMKI gamma, CaMKIG, CaMK-like CREB kinase III, CLICK III, CAMK1G, CLICK3, VWS1|
|Target/Specificity||This CAMK1G (CaMKI gamma) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 420-450 amino acids from the C-terminal region of human CAMK1G (CaMKI gamma).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CAMK1G (CaMKI gamma) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).|
|Cellular Location||Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein Cell membrane; Peripheral membrane protein|
|Tissue Location||Mainly expressed in brain with small amounts in skeletal muscles, kidney, spleen and liver. Strongly expressed in forebrain neocortex, striatum and limbic system|
Provided below are standard protocols that you may find useful for product applications.
Ca2+/calmodulin-dependent protein kinase I (CaMKI) constitutes a family of closely related isoforms (alpha, beta and gamma). CLICK-III/CaMKIgamma is a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase. AMKIgamma is abundant in neurons, particularly in the amygdala and ventromedial hypothalamus. Like the other CaMKI isoforms, full activation of CLICK-III/CaMKIgamma requires both Ca(2+)/CaM and phosphorylation by CaMKK.
Takemoto-Kimura, S., et al., J. Biol. Chem. 278(20):18597-18605 (2003).
Schutte, B.C., et al., Genome Res. 10(1):81-94 (2000).
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