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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RICTOR Antibody (Center)   

RICTOR Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RICTOR Antibody (Center) AP7259c
    RICTOR Antibody (Center) (Cat.#AP7259c) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the RICTOR antibody detected the RICTOR protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6R327
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 192218 Da
Antigen Region 805-835 aa
Additional Information
Gene ID 253260
Other Names Rapamycin-insensitive companion of mTOR, AVO3 homolog, hAVO3, RICTOR {ECO:0000312|EMBL:EAW559801}
Target/Specificity This RICTOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 805-835 amino acids from the Central region of human RICTOR.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRICTOR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RICTOR {ECO:0000312|EMBL:EAW55980.1}
Function Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Research Areas
Citations (0)

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RICTOR and MTOR (FRAP1) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth.


Pearce,L.R., Biochem. J. 405 (3), 513-522 (2007)
Yang,Q., Genes Dev. 20 (20), 2820-2832 (2006)
Jacinto,E., Cell 127 (1), 125-137 (2006)

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$ 295.00
$ 99.00
Cat# AP7259c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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