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REA (PHB2) Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP7270a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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REA (PHB2) Antibody (N-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | Q99623 |
| Other Accession | NP_009204 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 33296 Da |
REA (PHB2) Antibody (N-term) - Additional info | |
| Gene ID 11331 | |
| Other Names PHB2; BAP; REA; Prohibitin-2; B-cell receptor-associated protein BAP37; D-prohibitin; Repressor of estrogen receptor activity | |
| Target/Specificity This REA (PHB2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73~103 amino acids from the N-terminal region of human PHB2. | |
| Dilution WB~~1:50~100WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions REA (PHB2) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
REA (PHB2) Antibody (N-term) - Protein Information | |
| Name PHB2 | |
| Synonyms BAP, REA | |
| Function Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | |
| Cellular Location Mitochondrion inner membrane (By similarity). Cytoplasm (By similarity). Nucleus (By similarity) Note=Also cytoplasmic and nuclear (By similarity) | |
REA (PHB2) Antibody (N-term) - Related products
AP3539a: Phospho-PHB2-Y128 Antibody
AP3622a: Phospho-PHB2-pY248 Antibody
AP7270a: REA (PHB2) Antibody (N-term)
AP7270b: REA (PHB2) Antibody (C-term)
BP3539a: Phospho-PHB2-Y128 Antibody Blocking Peptide
BP3622a: Phospho-PHB2-pY248 Antibody Blocking Peptide
BP7270a: PHB2 Antibody (N-term) Blocking Peptide
REA (PHB2) Antibody (N-term) - Application data
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Western blot analysis of PHB2 (arrow) using rabbit polyclonal PHB2 Antibody (Human C-term) (Cat.#AP7270a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PHB2 gene (Lane 2) (Origene Technologies).
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Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PHB2 Antibody (N-term) (Cat.#AP7270a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
REA (PHB2) Antibody (N-term) - Research Areas
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BACKGROUND
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.
REFERENCES
Takata,H., Curr. Biol. 17 (15), 1356-1361 (2007) Kasashima,K., J. Biol. Chem. 281 (47), 36401-36410 (2006)
