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REA (PHB2) Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - REA (PHB2) Antibody (C-term) AP7270b
    Western blot analysis of anti-PHB2 Antibody (C-term) (Cat. #AP7270b) in 293 cell line lysates (35ug/lane). PHB2(arrow) was detected using the purified Pab.
    detail
  • WB - REA (PHB2) Antibody (C-term) AP7270b
    All lanes : Anti-PHB2 (Human C-term) at 1:1000 dilution Lane 1: 293 whole cell lysate Lane 2: Hela whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 33 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
    detail
  • IHC-P - REA (PHB2) Antibody (C-term) AP7270b
    Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PHB2 Antibody (C-term) (Cat.#AP7270b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q99623
Other Accession Q5XIH7, O35129, Q2HJ97, NP_009204
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 33296 Da
Antigen Region 197-226 aa
Additional Information
Gene ID 11331
Other Names Prohibitin-2, B-cell receptor-associated protein BAP37, D-prohibitin, Repressor of estrogen receptor activity, PHB2 {ECO:0000312|EMBL:AAH147661, ECO:0000312|HGNC:HGNC:30306}
Target/Specificity This REA (PHB2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-226 amino acids from the C-terminal region of human REA (PHB2).
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsREA (PHB2) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PHB2 {ECO:0000312|EMBL:AAH14766.1, ECO:0000312|HGNC:HGNC:30306}
Function Protein with pleiotropic attributes mediated in a cell- compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus.
Cellular Location Mitochondrion inner membrane. Cytoplasm. Nucleus. Cell membrane [Isoform 2]: Mitochondrion inner membrane
Research Areas
Citations (0)
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Background

Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

References

Takata,H., Curr. Biol. 17 (15), 1356-1361 (2007)
Kasashima,K., J. Biol. Chem. 281 (47), 36401-36410 (2006)

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$ 182.50
$ 70.00
Cat# AP7270b
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