|Application ||WB, IHC-P, E|
|Other Accession||Q62443, Q15818|
|Calculated MW||47216 Da|
|Antigen Region||364-393 aa|
|Other Names||Neuronal pentraxin-1, NP1, 47 kDa taipoxin-binding protein, Neuronal pentraxin I, NP-I, Nptx1|
|Target/Specificity||This NP1(Nptx1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from the C-terminal region of human NP1(Nptx1).|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NP1(Nptx1) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle|
|Tissue Location||Cerebellum, hippocampus and cerebral cortex.|
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Provided below are standard protocols that you may find useful for product applications.
NPTX1 is a member of the neuronal pentraxin gene family. Human neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin.
Hossain,M.A., J. Neurosci. 24 (17), 4187-4196 (2004)
Schlimgen,A.K., Neuron 14 (3), 519-526 (1995)
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