|Application ||WB, E|
|Other Accession||A5HK05, Q9DAX9, NP_006371|
|Calculated MW||66853 Da|
|Antigen Region||242-271 aa|
|Other Names||Amyloid protein-binding protein 2, Amyloid beta precursor protein-binding protein 2, APP-BP2, Protein interacting with APP tail 1, APPBP2, KIAA0228, PAT1|
|Target/Specificity||This PAT1(APPBP2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-271 amino acids from the Central region of human PAT1(APPBP2).|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAT1(APPBP2) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein Note=Associated with membranes and microtubules|
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Provided below are standard protocols that you may find useful for product applications.
APPBP2 interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This protein has been found to be highly expressed in breast cancer.
Zheng,P., Proc. Natl. Acad. Sci. U.S.A. 95 (25), 14745-14750 (1998)
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