|Application ||WB, IHC-P, E|
|Calculated MW||40880 Da|
|Antigen Region||283-314 aa|
|Other Names||Left-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B, LEFTY1, LEFTB, LEFTYB|
|Target/Specificity||This Lefty (LEFTB) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-314 amino acids from the C-terminal region of human Lefty (LEFTB).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Lefty (LEFTB) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for left-right axis determination as a regulator of LEFTY2 and NODAL.|
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Provided below are standard protocols that you may find useful for product applications.
LEFTB is a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products.
Kosaki K.,Am. J. Hum. Genet. 64:712-721(1999)
Dvash,T.,Stem Cells 25 (2), 465-472 (2007)
Besser,D.,J. Biol. Chem. 279 (43), 45076-45084 (2004)
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