|Application ||WB, IHC-P, E|
|Calculated MW||40880 Da|
|Antigen Region||283-314 aa|
|Other Names||Left-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B, LEFTY1, LEFTB, LEFTYB|
|Target/Specificity||This Lefty (LEFTB) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-314 amino acids from the C-terminal region of human Lefty (LEFTB).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Lefty (LEFTB) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for left-right axis determination as a regulator of LEFTY2 and NODAL.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
LEFTB is a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products.
Kosaki K.,Am. J. Hum. Genet. 64:712-721(1999)
Dvash,T.,Stem Cells 25 (2), 465-472 (2007)
Besser,D.,J. Biol. Chem. 279 (43), 45076-45084 (2004)
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