Lefty (LEFTB) Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | O75610 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 40880 Da |
Antigen Region | 283-314 aa |
Gene ID | 10637 |
---|---|
Other Names | Left-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B, LEFTY1, LEFTB, LEFTYB |
Target/Specificity | This Lefty (LEFTB) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-314 amino acids from the C-terminal region of human Lefty (LEFTB). |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Lefty (LEFTB) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LEFTY1 |
---|---|
Synonyms | LEFTB, LEFTYB |
Function | Required for left-right axis determination as a regulator of LEFTY2 and NODAL. |
Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
LEFTB is a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products.
References
Kosaki K.,Am. J. Hum. Genet. 64:712-721(1999)
Dvash,T.,Stem Cells 25 (2), 465-472 (2007)
Besser,D.,J. Biol. Chem. 279 (43), 45076-45084 (2004)
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