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GLRX2 Antibody (C-term T135)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q9NS18 |
| Other Accession | Q32L67 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 18052 Da |
| Antigen Region | 120-146 aa |
| Gene ID | 51022 |
|---|---|
| Other Names | Glutaredoxin-2, mitochondrial, GLRX2, GRX2 |
| Target/Specificity | This GLRX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-146 amino acids from the C-terminal region of human GLRX2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GLRX2 Antibody (C-term T135) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GLRX2 |
|---|---|
| Synonyms | GRX2 |
| Function | Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. |
| Cellular Location | [Isoform 1]: Mitochondrion. |
| Tissue Location | Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
GLRX2 are a family of glutathione-dependent hydrogen donors that participate in a variety of cellular redox reactions.
References
Lundberg M., Johansson C. J. Biol. Chem. 276:26269-26275(2001)
Gladyshev V.N., Liu A. J. Biol. Chem. 276:30374-30380(2001)
Lillig C.H. Proc. Natl. Acad. Sci. U.S.A. 101:13227-13232(2004)
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