|Application ||WB, FC, E|
|Calculated MW||37668 Da|
|Antigen Region||51-80 aa|
|Other Names||Carbonic anhydrase 14, Carbonate dehydratase XIV, Carbonic anhydrase XIV, CA-XIV, CA14|
|Target/Specificity||This CA14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-80 amino acids from the N-terminal region of human CA14.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CA14 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Reversible hydration of carbon dioxide.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
CA14 belongs a large family of zinc metalloenzymes that catalyze the versible hydration of carbon dioxide. The protein is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles.
Parkkila,S. Natl. Acad. Sci. U.S.A. 98 (4), 1918-1923 (2001)
Fujikawa-Adachi,K., Nishimori,I. Genomics 61 (1), 74-81 (1999)
Tarun,A.S., Bryant,B. Chem. Senses 28 (7), 621-629 (2003)
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