|Application ||WB, FC, E|
|Calculated MW||52771 Da|
|Antigen Region||295-322 aa|
|Other Names||BTB/POZ domain-containing protein 1, Hepatitis C virus NS5A-transactivated protein 8, HCV NS5A-transactivated protein 8, BTBD1, C15orf1, NS5ATP8|
|Target/Specificity||This BTBD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-322 amino acids from the Central region of human BTBD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BTBD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|
|Cellular Location||Cytoplasm, P-body. Note=Cytoplasmic bodies|
|Tissue Location||Ubiquitous; higher levels in heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
BTBD1 binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies.
Pisani,D.F., Cabane,C. Cell Death Differ. 11 (11), 1157-1165 (2004)
Xu,L., Yang,L. Exp. Cell Res. 288 (1), 84-93 (2003)
Xu,L., Yang,L. BMC Genomics 3 (1), 1 (2002)
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