|Application ||WB, E|
|Calculated MW||52286 Da|
|Antigen Region||52-81 aa|
|Other Names||Carboxypeptidase N catalytic chain, CPN, Anaphylatoxin inactivator, Arginine carboxypeptidase, Carboxypeptidase N polypeptide 1, Carboxypeptidase N small subunit, Kininase-1, Lysine carboxypeptidase, Plasma carboxypeptidase B, Serum carboxypeptidase N, SCPN, CPN1, ACBP|
|Target/Specificity||This CPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-81 amino acids from the N-terminal region of human CPN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CPN1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Synthesized in the liver and secreted in plasma|
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Provided below are standard protocols that you may find useful for product applications.
CPN1 is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The protein is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This protein is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits.
Davis,D.A., Singer,K.E. Blood 105 (12), 4561-4568 (2005)
Riley,D.A., Tan,F. Genomics 50 (1), 105-108 (1998)
Hendriks,D., Vingron,M. Biol. Chem. Hoppe-Seyler 374 (9), 843-849 (1993)
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